Maas Biolab Cyclosporin Neuroprotection Publications and Presentations.

Scientific Publications

Hansson MJ, Persson T, Friberg H, Keep MF, Rees A, Wieloch T, Elmer E. Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria. Brain Res. 960(1-2):99-111. Jan 17, 2003

Marcus Keep, Hiroyuki Uchino and Eskil Elmér. Introduction: Immunosuppressants as neuroprotective agents. In: Borlongan C., et.al (Eds.) Immunosuppressant Analogs in Neuroprotection. 3-32. Humana Press. 2002.

Marcus Keep, Keith S. K. Fong, Katalin Csiszar and Eskil Elmér. Cyclosporin-A prolongs survival of SOD1 mutant mice and implicates the mitochondrial permeability transition in ALS. In: Borlongan C., et.al (Eds.) Immunosuppressant Analogs in Neuroprotection. 343-359 Humana Press. 2002

Borlongan CV, Emerich DF, Hoffer BJ, Bartus RT.
Bradykinin receptor agonist facilitates low-dose cyclosporine-A protection against 6-hydroxydopamine neurotoxicity.
Brain Res. Nov 29;956(2):211-20. 2002

Karlsson J, Fong KSK, Elmer E, Csiszar K, Keep MF, Intraventricular Cyclosporin Prolongs Life Span and Reduces Neuronal Death in a Mouse Model of ALS (INTR-8 Abstracts). Experimental Neurology, Vol 175, No. 2, p. 442. June 2002.

Marcus Keep, Eskil Elmér, Keith S. K. Fong and Katalin Csiszar. Intrathecal cyclosporin prolongs survival of late stage ALS mice. Brain Research. 894: 327-331, 2001.

Borlongan CV, Stahl CE, Keep MF, Elmer E, and Watanabe S. Cyclosporine-A enhances choline acetyl-transferase immunoreactivity in the septal region of adult rats. Neuroscience Letters, 279: 73-76, 2000.

Alexi T, Borlongan CV, Faull RL, Williams CE, Clark RG, Gluckman PD, Hughes PE. Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases. Prog Neurobiol. Apr;60(5):409-70 2000

Siesjo BK, Elmer E, Janelidze S, Keep M, Kristian T, Ouyang YB, Uchino H. Role and mechanisms of secondary mitochondrial failure. In: Baethmann, A., Ringel, F. (Eds.) Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia. Acta Neurochirurgica (Suppl. 73): 7-13. Springer-Verlag Berlin. 1999

Uchino H., Elmér E., Uchino K., Li P-A., He Q-P., Smith M-L. and Siesjö B. K. Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat. 1998 Brain Res 812 (1-2), 216-26.

Li P-A., Uchino H., Elmér E. and Siesjö B. K. Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia. 1997, Brain Res. 753, 133-140.

Uchino H., Elmér E., Uchino K., Lindvall O and Siesjö B-K. Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischemia in the rat. 1995, Acta Physiol. Scand. 155, 469-471.

Maas Biolab Presentations

E Elmer, MJ Hansson, J Ohlsson, H Friberg, P Mouchet, A Rees, MF Keep. Characterization of cyclosporin inhibition of calcium-induced permeability transition in respiring CNS mitochondria. Society for Neuroscience 32 Annual Meeting. Orlando Florida. November 2002. Poster

MJ Hansson, T Persson, H Friberg, MF Keep, Arees, PP Mouchet, T Wieloch, E Elmer. Powerful cyclosporin inhibition of calcium-induced permeability transition in brain mitochondria. Society for Neuroscience 32 Annual Meeting. Orlando Florida. November 2002. Poster

Magnus J. Hansson, Jenny Karlsson, Marcus F. Keep, Eskil Elmér Neuroprotection through mitochondrial pore-blocking cyclosporins. Medicon Valley BioConference 2002. Scandinavian Biotech Arena. Malmö, Sweden. 8-10 October 2002. Poster

Karlsson J, Fong KSK, Elmer E, Csiszar K, Keep MF, Intraventricular Cyclosporin Prolongs Life Span and Reduces Neuronal Death in a Mouse Model of ALS. 8th International Conference on Neural Transplantation and Repair June 2002. Colorado. Poster

M. Keep and E. Elmér. Cyclosporin A: From Basic Science to Clinical Neuroprotection. Society for Neuroscience Satellite Symposium: Immunophilins in the Brain 2: Bridging the Gap Between Basic Research and Clinical Application. November 10, 2001. San Diego. Slide

C. Stahl, T. Kusayama, M.Keep, E. Elmer, S. Watanabe, and C.V. Borlongan. Cyclosporine-A improves performance in passive avoidance task in adult rats with basal forebrain lesions, Society for Neuroscience Meeting, November 11, 2001. San Diego. Poster